The Multidisciplinary Drifting Observatory for the Study of Arctic Climate (MOSAiC) was an international scientific expedition that drifted across the central Arctic from autumn 2019 to autumn 2020. The Second International MOSAiC Science Conference will be held at the University of Colorado Boulder. Conference objectives are to foster cross-cutting scientific analysis, address issues of spatiotemporal scaling of information, and promote advancement of modeling and predictive capabilities.